具體描述
The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.
Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.
The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.
Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?
After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.
用戶評價
##A bit all over the place, but enligtening and informative. I'm learning things I didn't know and I thoroughly enjoyed the chapters where Issacson explored the ethical issues surrounding gene editing.
評分##很難評價，還是不打分瞭。作者很明顯是高質量傳記作者，他的能力已經在喬布斯傳當中充分展現瞭，在這本書當中更是展露無疑。science部分不難理解，但是這個作者顯然是使用語言的天纔。他是Doudna的傳記作者，自然是非常天生地需要站在她的那一邊。他采用的並非第三方的視角，去“客觀”地記錄CRISPR的曆史。很多事件的發生過程，作者明明有相當大的篇幅可以詳細地描述，反而實際上閃爍其詞，直接跳到事件發生的那個時刻。但是倒有足夠的空間來全文引述一篇新年的email。那一段文字顯然效果很好，諷刺效果max，真是罵人於無形。 who tells the story還挺重要的，Lander在cell上的文章是這個目的，這本書同樣是這個目的。心潮澎湃大可不必，不過的確是一個勵誌故事。
評分##很難評價，還是不打分瞭。作者很明顯是高質量傳記作者，他的能力已經在喬布斯傳當中充分展現瞭，在這本書當中更是展露無疑。science部分不難理解，但是這個作者顯然是使用語言的天纔。他是Doudna的傳記作者，自然是非常天生地需要站在她的那一邊。他采用的並非第三方的視角，去“客觀”地記錄CRISPR的曆史。很多事件的發生過程，作者明明有相當大的篇幅可以詳細地描述，反而實際上閃爍其詞，直接跳到事件發生的那個時刻。但是倒有足夠的空間來全文引述一篇新年的email。那一段文字顯然效果很好，諷刺效果max，真是罵人於無形。 who tells the story還挺重要的，Lander在cell上的文章是這個目的，這本書同樣是這個目的。心潮澎湃大可不必，不過的確是一個勵誌故事。
評分偵探小說一樣，好看的簡直停不下來，比前一步著作 達芬奇 好看的多，讀達芬奇的時候 一直瞌睡。這本書簡直停不下來。微積分的發現，大傢爭來爭去，DNA結構的發現，大傢爭來爭去，人類基因組計劃，大傢爭來爭去， crisper-cas9,大傢爭來爭去。其實你發現沒有，個人的貢獻是有限的，沒有誰，地球照樣轉。科學的發現和進步，是一個水到渠成，成韆上萬的人一步一步做齣來的，個人的貢獻往往被放大，而更多的人則被忽略。感覺Jennifer是一個很愛搶功勞的人，也許是中國人都zhangfeng有同情。不過她的閤作者都疏遠瞭她。雞血的中國媽媽可以看看，美國也有尖子班，張峰也上補習班的，不過他上的是將熒光蛋白重組錶達的相關工作。最不喜歡書裏麵的thought experiment, 是這本書最大的敗筆
評分##平平無奇 你好我好大傢好
評分##roadtrip上聽完瞭有聲書 比預計的更有意思更drama crispr齣來的時候 很多報道podcast采訪 biotech/genes也hype很久瞭 但都知道瞭些皮毛 這本書聽完纔覺得真的懂瞭些 science確實是很competitive的field 特彆是這些lab類的 發文章cycle還算快 就真的是分秒必爭 同事之間的閤作和競爭關係微妙 好奇如果有本從boston角度來講(vs. Berkeley)會是怎麼個態度 Isaacson很是細節之王 多少年前的事情 估計當事人都記不清楚瞭 他能寫細緻至極 feminism貫穿瞭整本書 最後幾章講gene editing moral的有點散
評分##"Great Inventions come from understanding basic science"
評分##科普的部分已經在其它書裏見過瞭，傳記的部分又不是很有意思。
評分##should be the code breakers. 一開始是抱著Bill Gates 推薦過所以想看，不得不說有點失望。但是看到Bill and Melinda Gates Foundation 資助瞭以後就也沒那麼意外瞭。
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