具體描述
The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.
Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.
The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.
Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?
After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.
用戶評價
##其實應該叫The Code Breakers，除瞭Doudna and Charpentier, 作者對Zhang Feng的評價也很高，作者一直在強調對於基礎科學研究的重要性，在十四五計劃也有強調，期待各國能加大科研投入for a greater good
評分##除瞭學習科學知識 還藉鑒得到成功科學傢的品質 追求卓越注重閤作然而又能嚴格管理自己的時間界限 生命科學的魅力 疫情初期緊鑼密鼓的研究與疫苗開發 意外還有1984 vs. Brave New World這一對比重現 雖然有主POV CRISPR學術之爭的敘述個人感覺尚且公正 希望能多收集一些行傢綫報實驗室風雲!
評分##挺好看的，實效性很強，跟covid聯係很緊密。最喜歡看這種眾人拾柴火焰高，每個人的研究都為某個成功的發現奠定基石的故事。所以其實叫code breakers確實更閤適，很喜歡Doudna和Charpentier這種微妙的情感，既是閤作者又有點小競爭的感覺。中間有段講gene editing的好處和壞處覺得有點離題，好在後麵又拉迴來瞭
評分##很精彩的故事，高尖端的科技，科學傢的爭名奪利，關於道德的爭論，都很有意思，不過感覺作者夾帶私貨略多
評分##讀瞭Emmanuelle Charpentier, Feng Zhang, &He jiankui, CRISPR, Gene editing historic records部分，作者寫到science內容一筆帶過，想瞭解詳細內容自己去看文獻，曆史的部分講述得比較精彩，不搞學術的人讀瞭能看到研究進步發展時間綫上科學傢們的主導、參與、被遺忘、被放棄及存活的真實展現，good read
評分##最多3.5星吧。與其說這是一本傳記不如說是科普。然而作者寫科普書的能力遠不如其他專業學者。 關於基因編輯的道德問題作者花瞭很長的篇幅討論，這個話題寫幾本書都可以，作者在這方麵的理論知識顯然還不夠。道德問題誰都有權利發言，但寫太多瞭看著很乏味。 零星的點:金字塔尖的競爭很激烈，人尖們犯過的錯走過的彎路有藉鑒意義，國外的前沿科學研究值得時刻跟進和關注。
評分##很難評價，還是不打分瞭。作者很明顯是高質量傳記作者，他的能力已經在喬布斯傳當中充分展現瞭，在這本書當中更是展露無疑。science部分不難理解，但是這個作者顯然是使用語言的天纔。他是Doudna的傳記作者，自然是非常天生地需要站在她的那一邊。他采用的並非第三方的視角，去“客觀”地記錄CRISPR的曆史。很多事件的發生過程，作者明明有相當大的篇幅可以詳細地描述，反而實際上閃爍其詞，直接跳到事件發生的那個時刻。但是倒有足夠的空間來全文引述一篇新年的email。那一段文字顯然效果很好，諷刺效果max，真是罵人於無形。 who tells the story還挺重要的，Lander在cell上的文章是這個目的，這本書同樣是這個目的。心潮澎湃大可不必，不過的確是一個勵誌故事。
評分##這本書的寫法太悶瞭，吸引人的反而是那些爭議角色，比如口無遮攔的沃森，或者死捧弟子的Eric Lander，其他角色都立不起來。好在crispr周圍的抓馬就算遇到這種筆觸也絲毫沒有減少八點檔特質。倫理部分非常淺，有大段絲毫沒有建設性的“上帝”“自然”討論，這都什麼年代瞭。在我看來社交網絡還邪惡得要死呢，但人傢已經在這裏瞭，好好拆分和針對性解決吧。有朝一日我一定能等來有個性有文筆還不談上帝的生物學傢重寫這段往事的
評分##A bit all over the place, but enligtening and informative. I'm learning things I didn't know and I thoroughly enjoyed the chapters where Issacson explored the ethical issues surrounding gene editing.
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