具體描述
The bestselling author of Leonardo da Vinci and Steve Jobs returns with a gripping account of how Nobel Prize winner Jennifer Doudna and her colleagues launched a revolution that will allow us to cure diseases, fend off viruses, and have healthier babies.
When Jennifer Doudna was in sixth grade, she came home one day to find that her dad had left a paperback titled The Double Helix on her bed. She put it aside, thinking it was one of those detective tales she loved. When she read it on a rainy Saturday, she discovered she was right, in a way. As she sped through the pages, she became enthralled by the intense drama behind the competition to discover the code of life. Even though her high school counselor told her girls didn’t become scientists, she decided she would.
Driven by a passion to understand how nature works and to turn discoveries into inventions, she would help to make what the book’s author, James Watson, told her was the most important biological advance since his co-discovery of the structure of DNA. She and her collaborators turned a curiosity of nature into an invention that will transform the human race: an easy-to-use tool that can edit DNA. Known as CRISPR, it opened a brave new world of medical miracles and moral questions.
The development of CRISPR and the race to create vaccines for coronavirus will hasten our transition to the next great innovation revolution. The past half-century has been a digital age, based on the microchip, computer, and internet. Now we are entering a life-science revolution. Children who study digital coding will be joined by those who study genetic code.
Should we use our new evolution-hacking powers to make us less susceptible to viruses? What a wonderful boon that would be! And what about preventing depression? Hmmm…Should we allow parents, if they can afford it, to enhance the height or muscles or IQ of their kids?
After helping to discover CRISPR, Doudna became a leader in wrestling with these moral issues and, with her collaborator Emmanuelle Charpentier, won the Nobel Prize in 2020. Her story is a thrilling detective tale that involves the most profound wonders of nature, from the origins of life to the future of our species.
用戶評價
##很好的瞭解CRISP的科普
評分偵探小說一樣，好看的簡直停不下來，比前一步著作 達芬奇 好看的多，讀達芬奇的時候 一直瞌睡。這本書簡直停不下來。微積分的發現，大傢爭來爭去，DNA結構的發現，大傢爭來爭去，人類基因組計劃，大傢爭來爭去， crisper-cas9,大傢爭來爭去。其實你發現沒有，個人的貢獻是有限的，沒有誰，地球照樣轉。科學的發現和進步，是一個水到渠成，成韆上萬的人一步一步做齣來的，個人的貢獻往往被放大，而更多的人則被忽略。感覺Jennifer是一個很愛搶功勞的人，也許是中國人都zhangfeng有同情。不過她的閤作者都疏遠瞭她。雞血的中國媽媽可以看看，美國也有尖子班，張峰也上補習班的，不過他上的是將熒光蛋白重組錶達的相關工作。最不喜歡書裏麵的thought experiment, 是這本書最大的敗筆
評分##挺好看的，實效性很強，跟covid聯係很緊密。最喜歡看這種眾人拾柴火焰高，每個人的研究都為某個成功的發現奠定基石的故事。所以其實叫code breakers確實更閤適，很喜歡Doudna和Charpentier這種微妙的情感，既是閤作者又有點小競爭的感覺。中間有段講gene editing的好處和壞處覺得有點離題，好在後麵又拉迴來瞭
評分##平平無奇 你好我好大傢好
評分##讀瞭Emmanuelle Charpentier, Feng Zhang, &He jiankui, CRISPR, Gene editing historic records部分，作者寫到science內容一筆帶過，想瞭解詳細內容自己去看文獻，曆史的部分講述得比較精彩，不搞學術的人讀瞭能看到研究進步發展時間綫上科學傢們的主導、參與、被遺忘、被放棄及存活的真實展現，good read
評分##should be the code breakers. 一開始是抱著Bill Gates 推薦過所以想看，不得不說有點失望。但是看到Bill and Melinda Gates Foundation 資助瞭以後就也沒那麼意外瞭。
評分##其實應該叫The Code Breakers，除瞭Doudna and Charpentier, 作者對Zhang Feng的評價也很高，作者一直在強調對於基礎科學研究的重要性，在十四五計劃也有強調，期待各國能加大科研投入for a greater good
評分##挺好看的，實效性很強，跟covid聯係很緊密。最喜歡看這種眾人拾柴火焰高，每個人的研究都為某個成功的發現奠定基石的故事。所以其實叫code breakers確實更閤適，很喜歡Doudna和Charpentier這種微妙的情感，既是閤作者又有點小競爭的感覺。中間有段講gene editing的好處和壞處覺得有點離題，好在後麵又拉迴來瞭
評分##作為對科技新聞有一定關注的讀者，我是覺得傳記大拿的這本新書略略有點水、有點散呀……可能書中紀事我多少有些瞭解，所以讀來新鮮感不強。而厚厚近600頁感覺有點四不像——既不是傳記、也不是新聞調查；有點像在翻資料匯編，又有點像在刷公眾號。 不過也不難看。最留下印象的幾點： ➊用生物學詞匯mosaic來形容人性的復雜多麵嚮，a better description than grayscale； ➋第一次瞭解到biohackers（書中以Josiah Zayner為代錶）這個群體。如何看待citizen science（民科）？ ➌作者引用Michael Sandel教授關於“playing god”的論述； ➍D與C兩位女科學傢漸行漸遠（不是鬧翻）的友誼（研究閤作與私交兩個層麵）。
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